Product Description

IL-3Rβ Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES2616-50, ES2616-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: CSF2RB, IL3RB, IL5RB, Cytokine receptor common subunit beta, CDw131, GM-CSF/IL-3/IL-5 receptor common beta subunit, CD antigen CD131

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human IL-3R beta. AA range:559-608

Isotype: IgG

Target: IL-3Rβ

Specificity: IL-3Rβ Polyclonal Antibody detects endogenous levels of IL-3Rβ protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Placenta,

Observed Band (KD): 125kD

Fields: Cytokine-cytokine receptor interaction, Apoptosis, JAK-STAT signaling pathway, Pathways in cancer

Function: Disease: Defects in CSF2RB are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM: 265120]. PAP is an autosomal recessive fatal respiratory disease
Domain: The box 1 motif is required for JAK interaction and/or activation
Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding
Function: High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor
Similarity: Belongs to the type I cytokine receptor family. Type 4 subfamily
Similarity: Contains 2 fibronectin type-III domains
Subunit: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors

Subcellular Location: Membrane, Single-pass type I membrane protein

Storage and Stability: -20°C/1 year

Gene Name: CSF2RB

Protein Name: Cytokine receptor common subunit beta

Mouse Gene ID: 12983

Mouse SwissProt Number: P26955

Research Use Only