Product Description

Integrin alpha 11 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67244-50, MB67244-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Integrin α11, also known as type I collagen receptor, is a single-pass type I transmembrane protein that mediates cell-matrix adhesion and is part of the family of integrins that play a pivotal role in regμlation processes of cell proliferation, differentiation, migration, tumor invasion, and metastasis. Integrin α11 is highly expressed in embryonic fibroblasts and myofibroblasts and to varying degrees in the cytoplasm of most human tissues. In non-small cell lung cancers, integrin α11 overexpression correlates with tumorigenicity and formation of secondary metastatic lesions by increasing the migration and invasion capacity. TGFβ activation of integrin α11 resμlts in significant upregμlation and overexpression by cancer associated fibroblasts in the tumor stroma, therefore, it has been used as a prognostic marker in certain cancers. As a receptor for type I collagen, which is found in fibrotic tissue of the liver, lung, and kidney, integrin α11 colocalizes with α-smooth muscle actin. Type I collagen is the most abundant form in the body, indicating a role for targeting integrin α11 in the therapeutic intervention of fibrotic disease.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Integrin alpha-11

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Integrin alpha 11. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of Integrin alpha 11 protein.

Molecular Weight: ~ 160 kDa

Pathway: Regμlation of Actin Dynamics, G Protein-coupled Receptors Signaling to MAPK Erk, MAPK Erk in Growth and Differentiation Pathway(, PI3K AKT signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UKX5

Product: Mouse IgG2b kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only