Product Description

IRF-7 (phospho-Ser477) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES15428-50, ES15428-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, IHC

Alternate Names: Interferon regulatory factor 7 (IRF-7)

Clonality: Polyclonal

Immunogen: Synthesized phosho peptide around human IRF-7 (Ser477)

Isotype: IgG

Target: IRF-7

Specificity: This antibody detects endogenous levels of Human IRF-7 (phospho-Ser477),Mouse IRF-7 (phospho-Ser431), Rat IRF-7 (phospho-Ser429)

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed predominantly in spleen, thymus and peripheral blood leukocytes,

Observed Band (KD): 55kD

Fields: Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C, Hepatitis B, Measles, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Viral carcinogenesis, Lipid and atherosclerosis

Function: Function: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity. Activated by phosphorylation in response to infection. Activation leads to nuclear retention, DNA binding, and derepression of transactivation ability
Induction: By type I interferons
PTM: In response to a viral infection, phosphorylated on the C-terminal serine cluster. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3
Similarity: Belongs to the IRF family
Similarity: Contains 1 tryptophan pentad repeat DNA-binding domain
Subcellular Location: The phosphorylated and active form accumulates selectively in the nucleus
Subunit: Homodimer, phosphorylation-induced. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1, t

Subcellular Location: Nucleus Cytoplasm The phosphorylated and active form accumulates selectively in the nucleus

Storage and Stability: -20°C/1 year

Gene Name: IRF7

Protein Name: IRF-7 (Ser477)

Mouse Gene ID: 54123

Mouse SwissProt Number: P70434

Research Use Only