ITGA5 Monoclonal Antibody - BT-MCA3129

ITGA5 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3129-50, BT-MCA3129-100

Citations, Manuals and MSDS Available upon request.

Background: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.

Research Areas: Signal Transduction

Target Protein: ITGA5

Applications: IHC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 10F6

Host: Mouse

Isotype: Mouse IgG2a

Full Product Name: ITGA5

Immunogen: Purified recombinant fragment of human ITGA5 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 114kDa

UniProt Accession: P08648

Synonyms: FNRA, CD49e, VLA5A, ITGA5

GeneID: 3678

Research Use Only