Product Description

Jagged1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4131-50, ES4131-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IF, WB, IHC, ELISA

Alternate Names: JAG1, JAGL1, Protein jagged-1, Jagged1, hJ1, CD339

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human JAG1. AA range:981-1030

Isotype: IgG

Target: Jagged1

Specificity: Jagged1 Polyclonal Antibody detects endogenous levels of Jagged1 protein.

Dilution: IF: 1:50-200 Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Widely expressed in adult and fetal tissues, In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia, Expression is up-regulated in cervical squamous cell carcinoma, Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells,

Observed Band (KD): 140kD

Fields: Endocrine resistance, Notch signaling pathway, Apelin signaling pathway, Th1 and Th2 cell differentiation, TNF signaling pathway, Human papillomavirus infection, Pathways in cancer, Chemical carcinogenesis - receptor activation, Breast cancer

Function: Developmental Stage: Expressed in 32-52 days embryos in the distal cardiac outflow tract and pulmonary artery, major arteries, portal vein, optic vesicle, otocyst, branchial arches, metanephros, pancreas, mesocardium, around the major bronchial branches, and in the neural tube
Disease: Defects in JAG1 are a cause of tetralogy of Fallot (TOF) [MIM: 187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent
Disease: Defects in JAG1 are the cause of Alagille syndrome type 1 (ALGS1) [MIM: 118450]. Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis

Subcellular Location: Membrane, Single-pass type I membrane protein

Storage and Stability: -20°C/1 year

Gene Name: JAG1

Protein Name: Protein jagged-1

Mouse Gene ID: 16449

Mouse SwissProt Number: Q9QXX0

Rat Gene ID: 29146

Rat SwissProt Number: Q63722

Research Use Only