Product Description

JAK1 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66669-50, MB66669-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors. Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide mμltiple binding sites for signaling proteins. These associated signaling proteins, such as Stats, Shc, insμlin receptor substrates, and focal adhesion kinase (FAK), typically contain SH2 or other phospho-tyrosine-binding domains.

Category: Primary Antibody

Reactivity: Human, Rat

Host: Mouse

Applications: WB, IF/ICC, IP

Alternate Names: JAK1A, JAK1B, Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Purified recombinant human Jak1 protein fragments expressed in E.coli.

Dilution: WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100), IP (1/10 - 1/50)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of JAK1 protein.

Molecular Weight: ~ 130 kDa

Pathway: ErbB HER Signaling, Jak Stat: IL-6 Receptor Signaling, Inhibition of Apoptosis, PI3K AKT signaling.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P23458

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only