Product Description

JAK2 (phospho-Y570) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4610-50, BS4610-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Jak2 (Janus Kinase 2) belongs to the emerging family of non-receptor janus tyrosine kinases, which regμlate a spectrum of cellμlar functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimμli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated Jak2. Jak2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regμlate transcription. The canonical Jak-STAT pathway is integral to maintaining a normal immune system by stimμlating proliferation, differentiation, survival, and host resistance to pathogens. Altering Jak-STAT signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: JAK 2, JAK-2, JAK2, Janus Activating Kinase 2, Janus Kinase 2, Janus Kinase 2, JTK 10, JTK10,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human JAK2 around the phosphorylation site of Tyrosine 570.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-JAK2 (Y570) polyclonal antibody detects endogenous levels of JAK2 only when phosphorylated at Tyr570.

Molecular Weight: ~ 125 kDa

Pathway: Jak Stat: IL-6 Receptor Signaling, Inhibition of Apoptosis,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O60674

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only