Product Description

JNK1+JNK2+JNK3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65605-50, BS65605-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: JNK1(MAPK8) is a member of the MAP kinase family. JNK1 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. JNK2 (p54a, SAPK1a), along with JNK1 and JNK3, is thought to play an important role in nuclear signal transduction through its environmental stress activation and subsequent phosphorylation of the nuclear transcription factor p53. JNK3 is a neuron-specific form of c-Jun N-terminal kinases. Through its phosphorylation and nuclear localization, this kinase plays regμlatory roles in the signaling pathways of neuronal apoptosis. The JNK pathway is critically involved in diabetes and levels are abnormally elevated in obesity.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, (predicted: Dog, Pig, Cow, )

Host: Rabbit

Applications: WB, IHC-P

Alternate Names: JNK1 + JNK2 + JNK3, JNK1/2/3, JNK1+2+3, JNK1 + JNK2 + JNK3, MAPK10, c Jun N terminal kinase 1, c Jun N terminal kinase 2, c Jun N terminal kinase 3, JNK, JNK1, JNK2, JNK2ALPHA, JNK2BETA, JNK3, MAPK8, MAPK9, Mitogen activated protein kinase 10, Mitogen activated protein kinase 8, Mitogen activated protein kinase 9, SAPK(beta), Stress activated protein kinase JNK1, Stress activated protein kinase JNK2, Stress activated protein kinase JNK3, SAPK, p54a, JNK2A, JNK2B, PRKM9, JNK-55, SAPK1a, JNK2BETA, p54aSAPK, JNK2ALPHA.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human JNK1/2/3:151-250/384

Dilution: WB=1:500-2000 IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: JNK1+JNK2+JNK3 Polyclonal Antibody detects endogenous levels of JNK1+JNK2+JNK3 protein.

Molecular Weight: 42-52 kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q61831

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only