JNK3 Monoclonal Antibody - BT-MCA0802

JNK3 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0802-50, BT-MCA0802-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.

Research Areas: Signal transduction; Cancer; Neuroscience

Target Protein: MAPK10

Applications: WB, IF, ICC, ELISA

Reactivity: Human,Mouse

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Mitogen-activated protein kinase 10

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P53779; Mouse: Q61831

Synonyms: MAPK10; JNK3; JNK3A; PRKM10; SAPK1B; Mitogen-activated protein kinase 10; MAP kinase 10; MAPK 10; MAP kinase p49 3F12; Stress-activated protein kinase 1b; SAPK1b; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3

GeneID: Human: 5602

Research Use Only