Product Description

K1C40 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES15364-50, ES15364-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human K1C40 AA range: 143-193

Isotype: IgG

Target: K1C40

Specificity: This antibody detects endogenous levels of K1C40 at Human/Mouse/Rat

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in skin and scalp, Also very weakly expressed in tongue, breast, colon and small intestine, In the hair follicle, it is specifically present in the upper hair cuticle, Not present in the upper cortex (at protein level),

Molecular Weight (Da): 47kD

Fields: Estrogen signaling pathway, Staphylococcus aureus infection

Function: Developmental Stage: During differentiation of the hair, it is one of the last keratins expressed
Function: May play a role in late hair differentiation
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively)
Similarity: Belongs to the intermediate filament family
Subunit: Heterotetramer of two type I and two type II keratins
Tissue Specificity: Expressed in skin and scalp. Also very weakly expressed in tongue, breast, colon and small intestine. In the hair follicle, it is specifically present in the upper hair cuticle. Not present in the upper cortex (at protein level)

Subcellular Location: intermediate filament,

Storage and Stability: -20°C/1 year

Gene Name: KRT40 KA36

Protein Name: K1C40

Mouse Gene ID: 406221

Mouse SwissProt Number: Q6IFX3

Rat Gene ID: 287679

Rat SwissProt Number: Q6IFW2

Research Use Only