Product Description

KCC2B Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10807-50, ES10807-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: KCC2B,

Specificity: KCC2B Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.

Observed Band (KD): 73kD

Fields: ErbB signaling pathway, Calcium signaling pathway, cAMP signaling pathway, HIF-1 signaling pathway, Oocyte meiosis, Necroptosis, Adrenergic signaling in cardiomyocytes, Wnt signaling pathway, Axon guidance, Circadian entrainment, Long-term potentiation, Neurotrophin signaling pathway, Cholinergic synapse, Dopaminergic synapse, Olfactory transduction, Inflammatory mediator regulation of TRP channels, Insulin secretion, GnRH signaling pathway, Melanogenesis, Oxytocin signaling pathway, Glucagon signaling pathway, Aldosterone synthesis and secretion, Cushing syndrome, Gastric acid secretion, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Pathways in cancer, Proteoglycans in cancer, Glioma, Diabetic cardiomyopathy, Lipid and atherosclerosis

Function: Alternative Products: The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms, Catalytic Activity: ATP + a protein = ADP + a phosphoprotein. enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity. CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. Similarity: Belongs to the protein kinase superfamily. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Similarity: Contains 1 protein kinase domain. Subunit: CAMK2 is composed of four different

Subcellular Location: Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Sarcoplasmic reticulum membrane, Peripheral membrane protein, Cytoplasmic side Cell junction, synapse In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.

Storage and Stability: -20°C/1 year

Gene Name: CAMK2B, CAM2, CAMK2, CAMKB

Protein Name: Calcium/calmodulin-dependent protein kinase type II subunit beta, CaM kinase II subunit beta, CaMK-II subunit beta, EC 2.7.11.17

Human Gene ID: 816

Human SwissProt Number: Q13554

Mouse SwissProt Number: P28652

Rat SwissProt Number: P08413

Research Use Only