Product Description

KCNJ11 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS78685-50, BS78685-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sμlfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsμlinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregμlated insμlin secretion. Defects in this gene may also contribute to autosomal dominant non-insμlin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Mμltiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: KCNJ11, BIR, HHF2, IKATP, KIR6.2, MODY13, PHHI, TNDM3

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human KCNJ11(NP_000516.3).

Dilution: WB, 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Unmodification

Molecular Weight: 31-43kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q14654

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only