Product Description

KDEL Receptor 2 (L119) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS3123-50, BS3123-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P33947

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC, IF

All Applications: IHC: 1:50~1:200
IF: 1:50~1:200

Background: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of KDEL Receptor 2 (L119) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 24 kDa

Specificity: KDEL Receptor 2 (L119) polyclonal antibody detects endogenous levels of KDEL Receptor 2 protein.

Alternative Name: ER lumen protein retaining receptor 2; ERD2-like protein 1; ELP-1; ELP1; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2; KDELR2; ERD2.2

Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human KDEL Receptor 2.

Conjugate: Unconjugated

Modification: Unmodified