Product Description

KI2LA Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES9759-50, ES9759-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A(KIR2DL5A) Homo sapiens Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: KI2LA

Specificity: KI2LA Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Observed Band (KD): 41kD

Fields: Antigen processing and presentation, Natural killer cell mediated cytotoxicity, Graft-versus-host disease

Function: Function: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis
Similarity: Belongs to the immunoglobulin superfamily
Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains

Subcellular Location: Cell membrane, Single-pass type I membrane protein

Storage and Stability: -20°C/1 year

Gene Name: KIR2DL5A CD158F CD158F1 KIR2DL5

Protein Name: Killer cell immunoglobulin-like receptor 2DL5A (CD antigen CD158f1)

Research Use Only