Product Description

KIAA1967 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66478-50, MB66478-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Deleted in breast cancer gene 1 protein (DBC1) was originally identified by its localization to a region of chromosome 8p21 that is homozygously deleted in breast cancer. DBC1 is a large, nuclear protein with mμltiple functions in cell survival. It binds directly to the estrogen receptor α (ERα) hormone-binding domain in a ligand-independent manner and may be a key determinant of ligand-independent ERα expression and survival in human breast cancer cells . DBC1 can promote p53-mediated apoptosis by binding to and inhibiting the deacetylase activity of SirT1, resμlting in increased p53 acetylation levels and activity . DBC1 may be an important regμlator of heterochromatin formation as it binds SUV39H1 and inhibits its histone methyltransferase activity . Caspase-dependent processing activates the pro-apoptotic activity of DBC1 during Tumor Necrosis Factor-α (TNF-α)-mediated cell death signaling. This processing of DBC1 in response to TNF-α is an early event in the onset of apoptosis and resμlts in relocalization of DBC1 to the cytoplasm. Overexpression of the processed, cytoplasmic form of DBC1 resμlts in mitochondrial clustering and matrix condensation and sensitizes cells to TNF-α-mediated apoptosis.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Monkey

Host: Mouse

Applications: WB, IF/ICC, IP

Alternate Names: DBC1, KIAA1967, Cell cycle and apoptosis regμlator protein 2, Cell division cycle and apoptosis regμlator protein 2, DBIRD complex subunit KIAA1967, Deleted in breast cancer gene 1 protein, DBC-1, DBC.1, p30 DBC

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Purified recombinant human DBC1 protein fragments expressed in E.coli

Dilution: WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100), IP (1/10 - 1/50)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of KIAA1967 protein.

Molecular Weight: ~ 130 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8N163

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only