Product Description

KIF1B Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES15308-50, ES15308-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human KIF1B AA range: 1331-1381

Isotype: IgG

Target: KIF1B

Specificity: This antibody detects endogenous levels of KIF1B at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Isoform 3 is abundant in the skeletal muscle, It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine, Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas,

Molecular Weight (Da): 200kD

Function: Disease: Defects in KIF1B are the cause of Charcot-Marie-Tooth disease type 2A1 (CMT2A1) [MIM: 118210]. CMT2A1 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy
Function: Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility
Similarity: Belongs to the kinesin-like protein family
Similarity: Belongs to the kinesin-like protein family. U

Subcellular Location: Cytoplasm, cytoskeleton Mitochondrion Cell projection, axon, [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle

Storage and Stability: -20°C/1 year

Gene Name: KIF1B KIAA0591 KIAA1448

Protein Name: KIF1B

Mouse Gene ID: 16561

Mouse SwissProt Number: Q60575

Rat Gene ID: 117548

Rat SwissProt Number: O88658

Research Use Only