KIR3.1 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA26660-50, RA26660-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: potassium voltage-gated channel subfamily J member 3 (KCNJ3) Homo sapiens Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, at Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB, IF/ICC, ELISA Alternate Names: KCNJ3, GIRK1, G protein-activated inward rectifier potassium channel 1, GIRK-1, Inward rectifier K (+) channel Kir3.1, Potassium channel, inwardly rectifying subfamily J member 3 Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. Molecular Weight: 56 Protein Molecular Weight (kDa): 56 Storage: -20°C/1 year Human Gene ID: 3760 Human SwissProt Number: P48549 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only