KIT Monoclonal Antibody - BT-MCA2415

KIT Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2415-50, BT-MCA2415-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

Research Areas: Immunology

Target Protein: KIT

Applications: ICC, FCM

Clonality: Monoclonal

Clone ID: 1H1B1

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: KIT

Immunogen: Purified recombinant fragment of human KIT (AA: 23-322) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 110kDa

UniProt Accession: P10721

Synonyms: PBT, SCFR, C-Kit, CD117, MASTC

GeneID: 3815

Research Use Only