Product Description

KLF4 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66723-50, MB66723-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: KLF4 is a member of the erythroid Kruppel-like factor (EKLF) mμltigene family that is highly expressed in the differentiating layers of the epidermis. KLF4 plays a critical role in the differentiation of epithelial cells and is essential for normal gastric homeostasis. Depending on the target gene, KLF4 can function as both a repressor and activator of transcription. Research studies suggest this protein may function as either a tumor suppressor or an oncogene depending on tumor type, with up-regμlation in human squamous cell carcinoma of the head and neck and down-regμlation in colorectal carcinoma. The in vitro reprogramming of somatic cells to an embryonic-like state has been achieved by retroviral transduction of four factors: Oct-3/4, Sox2, c-Myc, and KLF4. These induced pluripotent stem cells (iPS) are of great therapeutic interest as they exhibit the key characteristics and growth properties of pluripotent stem cells.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IF/ICC, FC

Alternate Names: EZF, GKLF, Krueppel-like factor 4, Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human KLF4. The exact sequence is proprietary.

Dilution: WB (1/1000 - 1/2000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of KLF4 protein.

Molecular Weight: ~ 62 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O43474

Product: Mouse IgG2b kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only