KLHL13 Monoclonal Antibody - BT-MCA4530

KLHL13 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4530-50, BT-MCA4530-100

Citations, Manuals and MSDS Available upon request.

Background: KLHL13 (kelch-like 13), also known as BKLHD2 (BTB and kelch domain-containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate- specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Via its BTB and C-terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL-3 ligase.

Research Areas: Epigenetics and nuclear signaling, Cell biology

Target Protein: KLHL13

Applications: WB, IHC, ICC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 8D1

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: KLHL13

Immunogen: Purified recombinant fragment of human KLHL13 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 74kDa

UniProt Accession: Q9P2N7

Synonyms: BKLHD2, FLJ10262, MGC74791, KLHL13

GeneID: 90293

Research Use Only