KLHL22 Monoclonal Antibody - BT-MCA4753

KLHL22 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4753-50, BT-MCA4753-100

Citations, Manuals and MSDS Available upon request.

Background: KLHL22 (kelch-like protein 22) is a 634 amino acid protein that is related to the Drosophilakelch protein, which is required to maintain Actin organization in ovarian ring canals. Mutations affecting Kelch function result in the failure of Kelch to associate with the ring canals and subsequent female sterility. Human KLHL22 protein contains six kelch repeats and one BTB (POZ) domain. The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. There are two isoforms of KLHL22 that are produced as a result of alternative splicing events.

Research Areas: Epigenetics and nuclear signaling, Cell biology

Target Protein: KLHL22

Applications: WB, ICC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 7B10

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: KLHL22

Immunogen: Purified recombinant fragment of human KLHL22 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 72kDa

UniProt Accession: Q53GT1

Synonyms: KELCHL, KLHL22

GeneID: 84861

Research Use Only