[KO Validated] CD274 Rabbit pAb - A20481

[KO Validated] CD274 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A20481-20, A20481-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis.

Category: Polyclonal Antibodies

Applications: WB, ELISA

Cross-reactivity: Human, Mouse, Rat

Protein Weight: 33kDa

Observed Molecular Weight: 40-50kDa

Immunogen: Recombinant protein (or fragment)

Species: Mouse

GeneID: 60533

SWISS: Q9EP73

Alternate Names: B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik; 74

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

NCBI Alias: Cd274

Research Use Only