[KO Validated] CDK5 Rabbit pAb - A5730

[KO Validated] CDK5 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A5730-20, A5730-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants.

Category: Polyclonal Antibodies

Applications: WB, IF/ICC, IP, ELISA

Cross-reactivity: Human, Mouse, Rat

Protein Weight: 33kDa

Observed Molecular Weight: 30kDa

Immunogen: Recombinant protein (or fragment) .

Species: Human

GeneID: 1020

SWISS: Q00535

Alternate Names: LIS7; PSSALRE; K5

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:1000 IF/ICC, 1:10 - 1:100 IP, 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Cancer, Signal Transduction, G protein signaling, Kinase, Serine threonine kinases, Cell Biology Developmental Biology, Apoptosis, Cell Cycle, Endocrine Metabolism, Endocrine and metabolic diseases, Obesity, Immunology Inflammation, Cytokines, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease, Dopamine Signaling in Parkinson's Disease, Neurodegenerative Diseases Markers.

NCBI Alias: CDK5

Research Use Only