Product Description

LAMP2a Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90788-50, BS90788-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P13473

Host: Rabbit

Reactivity: Human, Rat, Mouse

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. LAMP-1 (also designated CD107A) and LAMP-2 (also designated CD107B) are involved in a variety of functions, including cellular adhesion, and are thought to participate in the process of tumor invasion and metastasis. Newly synthesized LAMP-1 and LAMP-2 proteins are sorted at the trans Golgi network and are transported intracellularly via a pathway that is distinct from the clathrin-coated vesicles used for the mannose-6 phosphate receptor. LAMP-1 is expressed on the surface of thrombin-activated but not resting platelets, and it is thought to be involved in the adhesive, prothrombic properties of these cells. Both LAMP-1 and LAMP-2 are involved in maintaining lysosome acidity and protecting the lysosomal membranes from autodigestion, and their expression is increased in patients with lysosomal storage disorders.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of LAMP2a polyclonal antibody at 1:500 dilution
Lane A: A375 cell membrane lysate (40ug)
Lane B: DLD cell membrane lysate (40ug)
Lane C: The Lung tissue lysate of Mouse (40ug)
Lane D: The Liver tissue lysate of Mouse (40ug)
Lane E: The Lung tissue lysate of Rat (40ug)
Lane F: The Liver tissue lysate of Rat (40ug)

Bioworld Molecular Weight: ~ 38 kDa

Specificity: LAMP2a polyclonal antibody detects endogenous levels of LAMP2a protein.

Alternative Name: Lysosome-associated membrane glycoprotein 2; LAMP-2; Lysosome-associated membrane protein 2; CD107 antigen-like family member B; LGP-96; CD107b; LAMP2

Immunogen: Synthetic peptide, corresponding to Human LAMP2a.

Conjugate: Unconjugated

Modification: Unmodified