Product Description

LAX1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11285-50, ES11285-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: function:Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.,induction:Up-regulated in T-cells following TCR engagement.,PTM:Phosphorylated on tyrosines by Syk, Lck or ZAP70 upon TCR or BCR activation, which leads to the recruitment of GRB2, PIK3R1 and GRAP2.,subunit:When phosphorylated, interacts with GRB2, PIK3R1 and GRAP2.,tissue specificity:Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 30-110

Isotype: IgG

Target: LAX1

Specificity: LAX1 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Expressed in spleen, thymus, and peripheral blood leukocytes, Expressed in several B-, T-, NK and monocyte cell lines,

Observed Band (KD): 43kD

Function: Function: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells
Induction: Up-regulated in T-cells following TCR engagement
PTM: Phosphorylated on tyrosines by Syk, Lck or ZAP70 upon TCR or BCR activation, which leads to the recruitment of GRB2, PIK3R1 and GRAP2
Subunit: When phosphorylated, interacts with GRB2, PIK3R1 and GRAP2
Tissue Specificity: Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines

Subcellular Location: Cell membrane, Single-pass type III membrane protein

Storage and Stability: -20°C/1 year

Gene Name: LAX1 LAX

Protein Name: Lymphocyte transmembrane adapter 1 (Linker for activation of X cells) (Membrane-associated adapter protein LAX)

Mouse SwissProt Number: Q8BHB3

Rat SwissProt Number: Q5FVQ5

Research Use Only