Product Description

Lck BP-1 (phospho Tyr397) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES5723-50, ES5723-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: developmental stage:Expressed in early stage of myeloid and erythroid differentiation.,function:Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.,PTM:Phosphorylated by LYN, rapidly after cross-linking of surface IgM on B-cells.,similarity:Contains 1 SH3 domain.,similarity:Contains 4 cortactin repeats.,subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3.,tissue specificity:Expressed only in tissues and cells of hematopoietic origin.,

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, IHC

Alternate Names: HCLS1, HS1, Hematopoietic lineage cell-specific protein, Hematopoietic cell-specific LYN substrate 1, LckBP1, p75

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human HS1 around the phosphorylation site of Tyr397. AA range:366-415

Isotype: IgG

Target: Lck BP-1

Specificity: Phospho-Lck BP-1 (Y397) Polyclonal Antibody detects endogenous levels of Lck BP-1 protein only when phosphorylated at Y397.

Dilution: WB 1:500-2000, IHC-p 1:50-300

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed only in tissues and cells of hematopoietic origin,

Observed Band (KD): 55kD

Fields: Tight junction, Bacterial invasion of epithelial cells, Pathogenic Escherichia coli infection, Shigellosis, Proteoglycans in cancer

Function: Developmental Stage: Expressed in early stage of myeloid and erythroid differentiation
Function: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression
PTM: Phosphorylated by LYN, rapidly after cross-linking of surface IgM on B-cells
Similarity: Contains 1 SH3 domain
Similarity: Contains 4 cortactin repeats
Subunit: Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to i

Subcellular Location: Membrane, Peripheral membrane protein Cytoplasm Mitochondrion

Storage and Stability: -20°C/1 year

Gene Name: HCLS1

Protein Name: Hematopoietic lineage cell-specific protein

Mouse SwissProt Number: P49710

Research Use Only