Product Description

Lck BP-1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA26834-50, RA26834-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: developmental stage:Expressed in early stage of myeloid and erythroid differentiation., function:Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression., PTM:Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells., similarity:Contains 1 SH3 domain., similarity:Contains 4 cortactin repeats., subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3., tissue specificity:Expressed only in tissues and cells of hematopoietic origin.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: HCLS1, HS1, Hematopoietic lineage cell-specific protein, Hematopoietic cell-specific LYN substrate 1, LckBP1, p75

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Molecular Weight: 54

Protein Molecular Weight (kDa): 54

Storage: -20°C/1 year

Human Gene ID: 3059

Human SwissProt Number: P14317

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only