Lck Monoclonal Antibody - BT-MCA2990

Lck Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2990-50, BT-MCA2990-100

Citations, Manuals and MSDS Available upon request.

Background: Lck (lymphocyte-specific protein tyrosine kinase), with 509-amino acid protein (about 56kDa), belongs to the Src non-receptor tyrosine kinases family. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Lck is expressed predominantly in T cells and is localized to the inner surface of the plasma membrane. Lck is activated after T cell stimulation and is required for T-cell proliferation and IL-2 production. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. In addition, inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection.

Research Areas: Immunology

Target Protein: Lck

Applications: WB

Reactivity: Human

Clonality: Monoclonal

Clone ID: 8E5F9

Host: Mouse

Isotype: Mouse IgG2a

Full Product Name: Lck

Immunogen: Purified recombinant fragment of human Lck expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 56kDa

UniProt Accession: P06239

Synonyms: YT16, p56lck, pp58lck

GeneID: 3932

Research Use Only