Product Description

LCK Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66812-50, MB66812-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Src is the human homolog of the v-Src gene of the Rous sarcoma virus, also known as avian sarcoma virus, or ASV. Src was the first proto-oncogenic, non-receptor tyrosine kinase characterized in human. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Src family kinases transduce signals that are involved in the control of a variety of cellμlar processes, including proliferation, differentiation, motility and adhesion. Src family kinases contain an amino terminal cell membrane anchor, followed by an SH3 domain and an SH2 domain that are involved in modμlar association and activation, respectively. Src family kinases are normally maintained in an inactive state and can be activated transiently during cellμlar events such as mitosis. Different subcellμlar localizations of Src family kinases may be important for the regμlation of specific cellμlar processes, such as mitogenesis, cytoskeletal organization and membrane trafficking. The Fyn and Lck Src family tyrosine kinases play a key role in T cell antigen receptor (TCR) signaling. The human Lck gene maps to chromosome 1p35.1 and encodes a 509 amino acid protein.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IHC, IF/ICC, FC

Alternate Names: Tyrosine-protein kinase Lck, Leukocyte C-terminal Src kinase, LSK, Lymphocyte cell-specific protein-tyrosine kinase, Protein YT16, Proto-oncogene Lck, T cell-specific protein-tyrosine kinase, p56-LCK

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human LCK. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/10 - 1/50), FC (1/10 - 1/50)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of LCK protein.

Molecular Weight: ~ 52 kDa

Pathway: G Protein-coupled Receptors Signaling to MAPK Erk, T cell receptor signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P06239

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only