Product Description

LDHA (phospho-Tyr10) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES15173-50, ES15173-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA, IHC

Alternate Names: L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59)

Clonality: Polyclonal

Immunogen: Synthesized phosho peptide around human LDHA (Tyr10)

Isotype: IgG

Target: LDHA

Specificity: This antibody detects endogenous levels of Human Mouse Rat LDHA (phospho-Tyr10)

Dilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Predominantly expressed in anaerobic tissues such as skeletal muscle and liver,

Observed Band (KD): 36kD

Fields: Glycolysis / Gluconeogenesis, Cysteine and methionine metabolism, Pyruvate metabolism, Propanoate metabolism, Metabolic pathways, HIF-1 signaling pathway, Glucagon signaling pathway, Central carbon metabolism in cancer

Function: Catalytic Activity: (S)-lactate + NAD(+) = pyruvate + NADH
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data
Disease: Defects in LDHA are a cause of exertional myoglobinuria
Online Information: Lactate dehydrogenase entry,Pathway: Fermentation, pyruvate fermentation to lactate, (S)-lactate from pyruvate: step 1/1
Similarity: Belongs to the LDH/MDH superfamily
Similarity: Belongs to the LDH/MDH superfamily. LDH family
Subunit: Homotetramer

Subcellular Location: Cytoplasm

Storage and Stability: -20°C/1 year

Gene Name: LDHA PIG19

Protein Name: LDHA (Tyr10)

Mouse Gene ID: 16828

Mouse SwissProt Number: P06151

Rat Gene ID: 24533

Rat SwissProt Number: P04642

Research Use Only