LEDGF Monoclonal Antibody - BT-MCA0843

LEDGF Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0843-50, BT-MCA0843-100

Citations, Manuals and MSDS Available upon request.

Background: A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9|11)(p22|p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.,domain:Residues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain).,function:Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator.

Research Areas: Epigenetics and nuclear signaling; Microbiology

Target Protein: PSIP1

Applications: WB, IHC-p, IF, ICC, ELISA

Reactivity: Human,Rat,Monkey

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: PC4 and SFRS1-interacting protein

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O75475; Mouse: Q99JF8; Rat: Q812D1

Synonyms: PSIP1; DFS70; LEDGF; PSIP2; PC4 and SFRS1-interacting protein; CLL-associated antigen KW-7; Dense fine speckles 70 kDa protein; DFS 70; Lens epithelium-derived growth factor; Transcriptional coactivator p75; p52

GeneID: Human: 11168313323

Research Use Only