Product Description

LFTY1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11122-50, ES11122-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein AA range: 121-170

Isotype: IgG

Target: LFTY1

Specificity: LFTY1 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Colon, Pancreas, Spleen, Teratocarcinoma,

Observed Band (KD): 40kD

Fields: TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells

Function: Function: Required for left-right axis determination as a regulator of LEFTY2 and NODAL
PTM: The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner
Similarity: Belongs to the TGF-beta family

Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: LEFTY1 LEFTB LEFTYB UNQ278/PRO317

Protein Name: Left-right determination factor 1 (Left-right determination factor B) (Protein lefty-1) (Protein lefty-B)

Mouse SwissProt Number: Q64280

Research Use Only