Product Description

LGR5 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11504-50, ES11504-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: LGR5,

Specificity: LGR5 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.

Observed Band (KD): 99kD

Fields: Wnt signaling pathway

Function: Orphan receptor. It may be an important receptor for signals controlling growth and differentiation of specific embryonic tissues. Similarity: Belongs to the G-protein coupled receptor 1 family. Similarity: Contains 17 LRR (leucine-rich) repeats. Tissue Specificity: Expressed in skeletal muscle, placenta, spinal cord, and various region of brain.

Subcellular Location: Cell membrane, Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane, Multi-pass membrane protein. Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864, however, the phosphorylation event has not been proven (PubMed:23439653).

Storage and Stability: -20°C/1 year

Gene Name: LGR5, GPR49, GPR67

Protein Name: Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38

Human Gene ID: 8549

Human SwissProt Number: O75473

Mouse SwissProt Number: Q9Z1P4

Research Use Only