LIN-28 Monoclonal Antibody - BT-MCA0845

LIN-28 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0845-50, BT-MCA0845-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues.

Research Areas: Epigenetics and nuclear signaling; Cancer

Target Protein: LIN28A

Applications: WB, IF, ICC, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Protein lin-28 homolog A

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9H9Z2; Mouse: Q8K3Y3

Synonyms: LIN28A; CSDD1; LIN28; ZCCHC1; Protein lin-28 homolog A; Lin-28A; Zinc finger CCHC domain-containing protein 1

GeneID: Human: 79727

Research Use Only