Lipin 1 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A14111-20, A14111-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Mouse, Rat
Protein Weight: 99kDa
Observed Molecular Weight: 130kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 23175
SWISS: Q14693
Alternate Names: PAP1; Lipin 1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cell Cycle, Cell differentiation, Endocrine Metabolism, Lipid Metabolism, Cholesterol Metabolism, Endocrine and metabolic diseases, Diabetes, Cardiovascular, Heart, Lipids, Cardiovascular diseases, Heart disease.
NCBI Alias: LPIN1
Research Use Only