LRP6 Monoclonal Antibody - BT-MCA3360

LRP6 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3360-50, BT-MCA3360-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

Research Areas: Signal transduction, Stem cells

Target Protein: LRP6

Applications: FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1A3F5

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: LRP6

Immunogen: Purified recombinant fragment of human LRP6 (AA: extra 1198-1370) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 180kDa

UniProt Accession: O75581

Synonyms: ADCAD2, STHAG7

GeneID: 4040

Research Use Only