Product Description

LULL1/TOR1AIP2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS65796-50, BS65796-100

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Swiss-Prot: Q8NFQ8

Host: Rabbit

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,

Applications: WB, IHC-P

All Applications: WB=1:500-2000 IHC-P=1:100-500

Background: LULL1 is a 470 amino acid endoplasmic reticulum single-pass membrane protein belonging to the TOR1AIP family. LULL1 interacts with torsinA, an essential AAA+ ATPase found in the endoplasmic reticulum (ER) and nuclear envelope (NE) of higher eukaryotes. LULL1 regulates the distribution and activity of torsinA within the ER and NE lumen and reveals functional defects in mutant torsinA, which is responsible for DYT1 dystonia, a neurodevelopmental disease caused by an in-frame deletion (Deltagag) in the gene encoding torsinA. The gene encoding LULL1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.

Purification and Purity: affinity purified by Protein A

Storage and Stability: Store at 4°C short term. Aliquot and store at -31°C long term. Avoid freeze-thaw cycles.

Specificity: LULL1 Polyclonal Antibody detects endogenous levels of LULL1 protein.

Bioworld Molecular Weight: ~56kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Primary: Anti-LULL1/TOR1AIP2 at 1/300 dilution, Primary: Anti-LULL1/TOR1AIP2 at 1/300 dilution, Primary: Anti-LULL1/TOR1AIP2 at 1/1000 dilution, Paraformaldehyde-fixed, paraffin embedded (mouse kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (LULL1) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C

Alternative Name: TOR1AIP2; IFRG15; Interferon responsive gene 15; LULL1; Lumenal domain like LAP1; NET9; RP11-12M5.5; TOR1AIP2; Torsin 1A interacting protein 2; Torsin A interacting protein 2.

Immunogen: KLH conjugated synthetic peptide derived from human LULL1:221-320/470

Conjugate: Unconjugated

Modification: Unmodified