LYN Monoclonal Antibody - BT-MCA2980

LYN Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2980-50, BT-MCA2980-100

Citations, Manuals and MSDS Available upon request.

Background: Lyn (also known as p53/56 Lyn) is a membrane-associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B-cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphor-ylate Tec on multiple residues. Lyn can also be regulated by IL-2 and IL-3.Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI).

Research Areas: Signal Transduction

Target Protein: LYN

Applications: WB

Reactivity: Human

Clonality: Monoclonal

Clone ID: 2H8D7

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: LYN

Immunogen: Purified recombinant fragment of LYN expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 56kDa

UniProt Accession: P07948

Synonyms: JTK8, FLJ26625

GeneID: 4067

Research Use Only