Product Description

MACC1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4022-50, ES4022-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: MACC1; Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human MACC1. AA range:411-460

Isotype: IgG

Target: MACC1,

Specificity: MACC1 Polyclonal Antibody detects endogenous levels of MACC1 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Preferentially expressed in metastasizing tumors.

Observed Band (KD): 97kD

Function: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. Similarity: Contains 1 SH3 domain. Subcellular Location: Mainly found in the cytoplasm in non-metastasizing tumors. Tissue Specificity: Preferentially expressed in metastasizing tumors.

Subcellular Location: Cytoplasm Nucleus Mainly found in the cytoplasm in non-metastasizing tumors.

Storage and Stability: -20°C/1 year

Gene Name: MACC1

Protein Name: Metastasis-associated in colon cancer protein 1

Human Gene ID: 346389

Human SwissProt Number: Q6ZN28

Research Use Only