Mammaglobin-A/B Monoclonal Antibody-MB66140

Mammaglobin-A/B Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB66140-50, MB66140-100

Product: Mouse IgG2a. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Swiss-Prot: O75556; Q13296

Host: Mouse

Reactivity: Human

Applications: IHC

All Applications: IHC (1/100 - 1/300)

Background: Mammaglobin is a gene that is expressed almost exclusively in the normal breast epithelium and human breast cancer. It is a member of the secretoglobin gene family and forms a heterodimer with lipophilin B. It has been suggested that mammaglobin may be a useful marker for breast cancer clinical research. Studies investigating the detection of mRNA by RT PCR from circulating carcinoma cells in the peripheral blood of breast cancer patients have shown that mammaglobin is a highly specific marker and correlates with several prognostic factors, such as lymph node involvement.

Purification and Purity: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemical analysis of Mammaglobin-A/B staining in human breast carcinoma formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6. 0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

Bioworld Molecular Weight: ~ 10 kDa

Specificity: Recognizes endogenous levels of Mammaglobin-A/B protein.

Alternative Name: LIPHC; MGB2; UGB3; Mammaglobin-B; Lacryglobin; Lipophilin-C; Mammaglobin-2; Secretoglobin family 2A member 1; MGB1; UGB2; Mammaglobin-A; Mammaglobin-1; Secretoglobin family 2A member 2

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human Mammaglobin-A/B. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified