Mammaglobin A Monoclonal Antibody-MB66078

Mammaglobin A Monoclonal Antibody Sizes: 50µl, 100µl Catalogue Numbers: MB66078-50, MB66078-100 Product: Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide. Swiss-Prot: Q13296 Host: Mouse Reactivity: Human Applications: IHC All Applications: IHC (1/100 - 1/300) Background: Secretoglobins (also called Lipophilins or Mammaglobins) are small secreted proteins of endocrine-responsive organs and mucosal epithelia that form multimeric complexes and correlate with the development of various human cancers. Lipophilin A and Lipophilin B are orthologs of prostatein (estramustinebinding protein), the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin A, also designated LIPA, LPHA and secretoglobin, family 1D, member 1 (SCGB1D1), is a component of a heterodimeric molecule present in human tears. Lipophilin B, also designated LIPB, LPHB and secretoglobin, family 1D, member 2 (SCGB1D2), mRNA can be overexpressed in breast tumors and shows a high degree of correlation with the mRNA expression profile of Mammaglobin. Histological detection in breast tissue of Mammaglobin A, also designated MGB1 and secretoglobin, family 2A, member 2 (SCGB2A2) and Mammaglobin B (also designated MGB2, Lipophilin C, LPHC, UGB3 and SCGB2A2) is a reliable diagnostic marker for breast tumors. Purification and Purity: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Note: For research use only, not for use in diagnostic procedure. Extra Notes: Immunohistochemical analysis of Mammaglobin A staining in human breast carcinoma formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6. 0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Bioworld Molecular Weight: ~ 10 kDa Specificity: Recognizes endogenous levels of Mammaglobin A protein. Alternative Name: MGB1; UGB2; Mammaglobin-A; Mammaglobin-1; Secretoglobin family 2A member 2 Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human Mammaglobin A. The exact sequence is proprietary. Conjugate: Unconjugated Modification: Unmodified