MAP2K4 Monoclonal Antibody - BT-MCA2146

MAP2K4 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2146-50, BT-MCA2146-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues .

Research Areas: Signal Transduction

Target Protein: MAP2K4

Applications: WB, IHC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 5H4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: MAP2K4

Immunogen: Purified recombinant fragment of human MAP2K4 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 42kDa

UniProt Accession: P45985

Synonyms: JNKK, MEK4, MKK4, SEK1, JNKK1, SERK1, MAPKK4, PRKMK4, MAP2K4

GeneID: 6416

Research Use Only