MAPK10 Monoclonal Antibody - BT-MCA2495

MAPK10 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2495-50, BT-MCA2495-100

Citations, Manuals and MSDS Available upon request.

Background: MAPK10: mitogen-activated protein kinase 10, also known as JNK3, JNK3A, PRKM10, p54bSAPK. Entrez Protein NP_002744. It is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Research Areas: Neuroscience

Target Protein: MAPK10

Applications: WB, ICC

Reactivity: Human, Mouse

Clonality: Monoclonal

Clone ID: 10E4A4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: MAPK10

Immunogen: Purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 53kDa

UniProt Accession: P53779

Synonyms: JNK3, JNK3A, PRKM10, p54bSAPK

GeneID: 5602

Research Use Only