MAPK8 Monoclonal Antibody - BT-MCA3361

MAPK8 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3361-50, BT-MCA3361-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Research Areas: Others

Target Protein: MAPK8

Applications: WB, FCM

Reactivity: Human, Mouse

Clonality: Monoclonal

Clone ID: 1E5

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: MAPK8

Immunogen: Purified recombinant fragment of human MAPK8 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 48.3kDa

UniProt Accession: P45983

Synonyms: JNK, JNK1, PRKM8, SAPK1, JNK-46, JNK1A2, SAPK1c, JNK21B1/2

GeneID: 5599

Research Use Only