Product Description

MAPKAPK-2 (phospho Ser272) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65376-50, BS65376-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: mitogen-activated protein kinase-activated protein kinase 2(MAPKAPK2) Homo sapiens This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regμlated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellμlar processes including stress and inflammatory responses, nuclear export, gene expression regμlation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jμl 2008],

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC-p, IF(paraffin, section), ELISA

Alternate Names: MAPKAPK2, MAP kinase-activated protein kinase 2, MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAP-K2, MAPKAPK-2, MK-2, MK2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: The antiserum was produced against synthesized peptide derived from human MAPKAPK2 around the phosphorylation site of Ser272. AA range:238-287

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity: Phospho-MAPKAPK-2 (S272) Polyclonal Antibody detects endogenous levels of MAPKAPK-2 protein only when phosphorylated at S272.

Molecular Weight: ~45-52 kDa

Pathway: Regμlation of Microtubμle Dynamics, Signaling Pathways Activating p38 MAP Kinase

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P49137

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only