Product Description

MARCH3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4652-50, ES4652-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013],

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: MARCH3, RNF173, E3 ubiquitin-protein ligase MARCH3, Membrane-associated RING finger protein 3, Membrane-associated RING-CH protein III, MARCH-III, RING finger protein 173

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human MARCH3. AA range:111-160

Isotype: IgG

Target: MARCH3

Specificity: MARCH3 Polyclonal Antibody detects endogenous levels of 40605 protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Thalamus,

Observed Band (KD): 29kD

Function: Domain: The RING-CH-type zinc finger domain is required for E3 ligase activity
Function: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates
Pathway: Protein modification, protein ubiquitination
Similarity: Contains 1 RING-CH-type zinc finger
Subunit: Interacts with MARCH2 and STX6

Subcellular Location: Cytoplasmic vesicle membrane, Multi-pass membrane protein Early endosome membrane, Multi-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: MARCH3

Protein Name: E3 ubiquitin-protein ligase MARCH3

Mouse Gene ID: 320253

Mouse SwissProt Number: Q8BRX9

Rat Gene ID: 364878

Rat SwissProt Number: Q5XIE5

Research Use Only