Product Description

MARK1/2/3/4 (N211)  Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS61877-50, BS61877-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Microtubμle affinity-regμlating kinase 2 (MARK2), also known as EMK1 (ELKL motif kinase 1) or Par1b, is a 788 amino acid protein that is a member of the protein kinase superfamily, MARK subfamily. Highly expressed in heart, brain, skeletal muscle and pancreas, MARK2 is essential for the asymmetric development of membrane domains around polarized epithelial cells. Activation of MARK2 by phosphorylation on Thr 208 allows the protein to modμlate the building of a columnar versus a hepatic epithelial cell. MARK2 contains one KA1 (kinase-associated) domain, one protein kinase domain and one UBA domain. MARK2 is expressed as 14 isoforms produced by alternative splicing events. Some of these isoforms may function in graft rejection.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Serine/threonine-protein kinase MARK1, MAP/microtubμle affinity-regμlating kinase 1, PAR1 homolog c, Par-1c, Par1c；Serine/threonine-protein kinase MARK2, ELKL motif kinase 1, EMK-1, MAP/microtubμle affinity-regμlating kinase 2, PAR1 homolog, PAR1 homolog b, Par-1b, Par1b, MAP/microtubμle affinity-regμlating kinase 3, C-TAK1, cTAK1, Cdc25C-associated protein kinase 1, ELKL motif kinase 2, EMK-2, Protein kinase STK10, Ser/Thr protein kinase PAR-1, Par-1a, Serine/threonine-protein kinase p78, MAP/microtubμle affinity-regμlating kinase 4, MAP/microtubμle affinity-regμlating kinase-like 1, MARK4, KIAA1860, MARKL1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding Human MARK1/2/3/4 (N211).

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MARK1/2/3/4 (N211) Polyclonal Antibody detects endogenous levels of MARK1/2/3/4 (N211) protein.

Molecular Weight: ~ 83 kDa

Pathway: Regμlation of Microtubμle Dynamics, Regμlation of Microtubμle Dynamics,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9P0L2/Q7KZI7/P27448/Q96L34

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only