MBP Monoclonal Antibody - BT-MCA4629

MBP Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4629-50, BT-MCA4629-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Research Areas: Neuroscience, Tags and cell markers

Target Protein: MBP

Applications: IHC, ICC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 2H9

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: MBP

Immunogen: Purified recombinant fragment of human MBP expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 33kDa

UniProt Accession: P02686

Synonyms: MGC99675

GeneID: 4155

Research Use Only