Product Description

MCM3 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA27090-50, RA27090-100

Citations, Manuals and MSDS Available upon request.

Background: minichromosome maintenance complex component 3 (MCM3) Homo sapiens The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

Alternative Names: MCM3; DNA replication licensing factor MCM3; DNA polymerase alpha holoenzyme-associated protein P1; P1-MCM3; RLF subunit beta; p102

Applications: WB; IHC-p; IF (paraffin section) ; ELISA

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 4172

Protein MW (KDa): 89

SWISS: P25205

Source: Rabbit

Research Use Only