Product Description

MCM7 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA27095-50, RA27095-100

Citations, Manuals and MSDS Available upon request.

Background: minichromosome maintenance complex component 7 (MCM7) Homo sapiens The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: IHC-p 1:50-200, WB 1:500-2000

Alternative Names: DNA replication licensing factor MCM7 (EC 3.6.4.12;CDC47 homolog;P1.1-MCM3)

Applications: IHC-p; IF (paraffin section) ; WB

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 4176

Protein MW (KDa): 79

SWISS: P33993

Source: Rabbit

Research Use Only